Endocrine Abstracts

Introduction: Parabens, esters of para-hydroxybenzoic acid, are widely used as an antimicrobial agent in the cosmetic products and pharmaceutical industries. Recently, it has been reported that parabens including methyl-, ethyl-, propyl-, butyl-, isopropyl-, and isobutylparaben act as xenoestrogens, a class of endocrine disruptors. In this study, we hypothesized that parabens may disrupt ovarian follicle maturation in female rats during the neonatal period.<p class="abstex...

Introduction: Octylphenol (OP) is a degradation product of alkylphenol ethoxylates that are widely used to in rubber, pesticides and paints. Bisphenol A (BPA) is an organic compound with two functional phenol groups and used to make polycarbonate plastic and epoxy resins, along with other applications. OP and BPA are known as endocrine disruptors that can induce inappropriate estrogenic action, and may disturb natural calcium metabolism. In the present study, the effects of OP...

Introduction: Preeclampsia is a pregnancy-specific disease characterized by de novo development of concurrent hypertension, proteinuria and oxidative stress in placenta. Hypoxia occurs during the development of placenta in the first trimester and is implicated in trophoblast differentiation. The oxidative stress, resulting from deficient remodeling of spiral arteries, is an important inducer of preeclampsia. The potassium-dependent sodium/calcium exchangers including NC...

Introduction: Preeclampsia is a pregnancy-specific disease characterized by de novo development of concurrent hypertension, proteinuria and oxidative stress in the placenta. Hypoxia occurs during the development of placenta in the first trimester and is implicated in trophoblast differentiation. Last trimester of gestation, the calcium and mineral transport from mother to fetus are dramatically increased in response to the accelerated demand for bone mineralization in t...

Aim: To assess the effects of a continuous overnight infusion of two doses of UAG (3&10 μg UAG/kg.hr-1) versus placebo in a double blind cross-over study on AG levels, as well on glucose and insulin response to a standard breakfast meal (SBM) in 8 overweight patients with type 2 diabetes (HbA1c 6.5-7.5%).Methods: During these 3 admissions, in randomized order, all subjects received either placebo, or UAG 3 μg/kg.hr-1 or UAG 10 μg/kg.hr...